4AJM

Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors

Summary for 4AJM

• Entry DOI: 10.2210/pdb4ajm/pdb
• Related: 1LRB 2WEY 2Y0J 4AEL 4AJD 4AJF 4AJG
• Descriptor: CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 76499.12

Authors

Geschwindner, S.,Johansson, P.,Spadola, L.,Akerud, T.,Back, E.,Hillertz, P.,Horsefeld, R.,Scott, C.,Spear, N.,Tian, G.,Tigerstrom, A.,Aharony, D.,Albert, J.S. (deposition date: 2012-02-16, release date: 2013-03-06)

• Primary citation: Geschwindner, S.,Johansson, P.,Spadola, L.,Akerud, T.,Back, E.,Hillertz, P.,Horsefeld, R.,Scott, C.,Spear, N.,Tian, G.,Tigerstrom, A.,Aharony, D.,Albert, J.S.; Development of a Plate-Based Optical Biosensor Methodology to Identify Pde10 Fragment Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)