2Y0J

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation.

Summary for 2Y0J

Entry DOI	10.2210/pdb2y0j/pdb
Related	1LRB 2WEY
Descriptor	CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, 5-(1H-BENZIMIDAZOL-2-YLMETHYLSULFANYL)-2-METHYL-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	80125.31
Authors	Kehler, J.,Ritzen, A.,Langgard, M.,Petersen, S.L.,Christoffersen, C.T.,Nielsen, J.,Kilburn, J.P. (deposition date: 2010-12-03, release date: 2011-06-15, Last modification date: 2023-12-20)
Primary citation	Kehler, J.,Ritzen, A.,Langgard, M.,Petersen, S.L.,Farah, M.M.,Bundgaard, C.,Christoffersen, C.T.,Nielsen, J.,Kilburn, J.P. Triazoloquinazolines as a Novel Class of Phosphodiesterase 10A (Pde10A) Inhibitors. Bioorg.Med.Chem.Lett., 21:3738-, 2011 Cited by PubMed: 21602043 DOI: 10.1016/J.BMCL.2011.04.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation