2Y0J
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation.
Summary for 2Y0J
Entry DOI | 10.2210/pdb2y0j/pdb |
Related | 1LRB 2WEY |
Descriptor | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, 5-(1H-BENZIMIDAZOL-2-YLMETHYLSULFANYL)-2-METHYL-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80125.31 |
Authors | Kehler, J.,Ritzen, A.,Langgard, M.,Petersen, S.L.,Christoffersen, C.T.,Nielsen, J.,Kilburn, J.P. (deposition date: 2010-12-03, release date: 2011-06-15, Last modification date: 2023-12-20) |
Primary citation | Kehler, J.,Ritzen, A.,Langgard, M.,Petersen, S.L.,Farah, M.M.,Bundgaard, C.,Christoffersen, C.T.,Nielsen, J.,Kilburn, J.P. Triazoloquinazolines as a Novel Class of Phosphodiesterase 10A (Pde10A) Inhibitors. Bioorg.Med.Chem.Lett., 21:3738-, 2011 Cited by PubMed: 21602043DOI: 10.1016/J.BMCL.2011.04.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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