4AJM
Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors
Summary for 4AJM
Entry DOI | 10.2210/pdb4ajm/pdb |
Related | 1LRB 2WEY 2Y0J 4AEL 4AJD 4AJF 4AJG |
Descriptor | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 76499.12 |
Authors | Geschwindner, S.,Johansson, P.,Spadola, L.,Akerud, T.,Back, E.,Hillertz, P.,Horsefeld, R.,Scott, C.,Spear, N.,Tian, G.,Tigerstrom, A.,Aharony, D.,Albert, J.S. (deposition date: 2012-02-16, release date: 2013-03-06, Last modification date: 2024-05-08) |
Primary citation | Geschwindner, S.,Johansson, P.,Spadola, L.,Akerud, T.,Back, E.,Hillertz, P.,Horsefeld, R.,Scott, C.,Spear, N.,Tian, G.,Tigerstrom, A.,Aharony, D.,Albert, J.S. Development of a Plate-Based Optical Biosensor Methodology to Identify Pde10 Fragment Inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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