4AJM

Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1402

Chain	Residue
A	HIS529
A	HIS563
A	ASP564
A	ASP674
A	HOH2029

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1403

Chain	Residue
A	HOH2030
A	HOH2034
A	ASP564
A	HOH2024
A	HOH2028
A	HOH2029

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 1402

Chain	Residue
D	HIS529
D	HIS563
D	ASP564
D	ASP674
D	HOH2026

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 1403

Chain	Residue
D	ASP564
D	THR633
D	HOH2022
D	HOH2025
D	HOH2026
D	HOH2027
D	HOH2033

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site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3A6 D 1769

Chain	Residue
A	LYS686
D	VAL678
D	ILE692
D	TYR693
D	PHE696
D	PRO712
D	MET713
D	LYS718
D	GLU721
D	VAL722
D	GLY725
D	GLN726
D	PHE729

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Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY

Chain	Residue	Details
A	HIS563-TYR574

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF

Chain	Residue	Details
A	ASN572
A	SER616
A	GLN650
A	MET669
D	ASN572
D	SER616
D	GLN650
D	MET669

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