2WEY

Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals

Summary for 2WEY

• Entry DOI: 10.2210/pdb2wey/pdb
• Related: 1LRB
• Descriptor: CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, ZINC ION, ... (5 entities in total)
• Functional Keywords: metal-binding, cross-linking, phosphoprotein, phosphodiesterase, allosteric enzyme, cgmp, camp, zinc, hydrolase, cytoplasm, magnesium, papaverine, polymorphism, cgmp-binding, camp-binding, nucleotide-binding, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 79782.80

Authors

Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J. (deposition date: 2009-04-02, release date: 2009-07-28, Last modification date: 2024-01-31)

• Primary citation: Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J.; Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure.; Acta Crystallogr.,Sect.D, 65:872-, 2009; PubMed: 19622871; DOI: 10.1107/S0907444909017855

Experimental method

X-RAY DIFFRACTION (2.8 Å)