4A9U

CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR

Summary for 4A9U

Entry DOI	10.2210/pdb4a9u/pdb
Related	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 4A9R 4A9S 4A9T
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK2, NITRATE ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	1
Total formula weight	38208.45
Authors	Matijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,van Montfort, R.L.M.,Blagg, J. (deposition date: 2011-11-28, release date: 2012-10-10, Last modification date: 2023-12-20)
Primary citation	Matijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,Van Montfort, R.L.M.,Blagg, J. Benzimidazole Inhibitors of the Protein Kinase Chk2: Clarification of the Binding Mode by Flexible Side Chain Docking and Protein-Ligand Crystallography Bioorg.Med.Chem., 20:6630-, 2012 Cited by PubMed: 23058106 DOI: 10.1016/J.BMC.2012.09.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation