3ZZD

Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 85

Summary for 3ZZD

• Entry DOI: 10.2210/pdb3zzd/pdb
• Related: 3ZYD 3ZYE 3ZZ3 3ZZ4 3ZZ5 3ZZ6 3ZZ7 3ZZ8 3ZZ9 3ZZA 3ZZB 3ZZC
• Descriptor: 3C PROTEINASE, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total)
• Functional Keywords: hydrolase, picornaviridae, beta-unsaturated ethyl ester inhibitor
• Biological source: HUMAN COXSACKIEVIRUS
• Total number of polymer chains: 1
• Total formula weight: 20970.12

Authors

Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-08-31, release date: 2012-09-19, Last modification date: 2019-05-08)

• Primary citation: Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R.; Peptidic Alpha, Beta-Unsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)