3ZZ8
Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 82
Summary for 3ZZ8
Entry DOI | 10.2210/pdb3zz8/pdb |
Related | 3ZYD 3ZYE 3ZZ3 3ZZ4 3ZZ5 3ZZ6 3ZZ7 3ZZ9 3ZZA 3ZZB 3ZZC 3ZZD |
Descriptor | 3C PROTEINASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE (3 entities in total) |
Functional Keywords | hydrolase, picornaviridae, beta-unsaturated ethyl ester inhibitor |
Biological source | HUMAN COXSACKIEVIRUS |
Total number of polymer chains | 1 |
Total formula weight | 21124.30 |
Authors | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-08-31, release date: 2012-09-19, Last modification date: 2024-05-01) |
Primary citation | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. Peptidic Alpha, Beta-Unsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations To be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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