3ZZ6

Crystal structure of 3C protease of coxsackievirus B3 complexed with Michael receptor inhibitor 75

Summary for 3ZZ6

• Entry DOI: 10.2210/pdb3zz6/pdb
• Related: 3ZYD 3ZYE 3ZZ3 3ZZ4 3ZZ5 3ZZ7 3ZZ8 3ZZ9 3ZZA 3ZZB 3ZZC 3ZZD
• Descriptor: POLYPROTEIN 3BCD, ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE (3 entities in total)
• Functional Keywords: picornaviridae, hydrolase, michael receptor inhibitor
• Biological source: HUMAN COXSACKIEVIRUS B3
• Total number of polymer chains: 1
• Total formula weight: 20939.08

Authors

Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-08-31, release date: 2012-09-19, Last modification date: 2019-05-08)

• Primary citation: Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R.; Peptidic Ab-Nonsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)