3ZZA
Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 84
Summary for 3ZZA
Entry DOI | 10.2210/pdb3zza/pdb |
Related | 3ZYD 3ZYE 3ZZ3 3ZZ4 3ZZ5 3ZZ6 3ZZ7 3ZZ8 3ZZB 3ZZC 3ZZD |
Descriptor | 3C PROTEINASE, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total) |
Functional Keywords | hydrolase, picornaviridae |
Biological source | HUMAN COXSACKIEVIRUS |
Total number of polymer chains | 1 |
Total formula weight | 21184.40 |
Authors | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-08-31, release date: 2012-09-19, Last modification date: 2019-05-08) |
Primary citation | Tan, J.,Anand, K.,Mesters, J.R.,Hilgenfeld, R. Peptidic Alpha, Beta-Unsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations To be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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