3UG2
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
Summary for 3UG2
Entry DOI | 10.2210/pdb3ug2/pdb |
Related | 2EB2 2EB3 3UG1 3VJN 3VJO |
Descriptor | Epidermal growth factor receptor, Gefitinib, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | kinase, tyrosine-protein kinase, atp binding, phosphorylation, transmembrane, receptor, disease mutation, cell cycle, drug resistance, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38680.19 |
Authors | Parker, L.J.,Handa, N.,Yoshikawa, S.,Kukimoto-Niino, M.,Shirouzu, M.,Yokoyama, S. (deposition date: 2011-11-02, release date: 2012-03-07, Last modification date: 2023-11-01) |
Primary citation | Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Oncogene, 32:27-38, 2013 Cited by PubMed: 22349823DOI: 10.1038/onc.2012.21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report