2EB2

Crystal structure of mutated EGFR kinase domain (G719S)

Summary for 2EB2

Entry DOI	10.2210/pdb2eb2/pdb
Related	2EB3 3UG1 3UG2 3VJN 3VJO
Descriptor	Epidermal growth factor receptor (2 entities in total)
Functional Keywords	kinase, tyrosine-protein kinase, receptor, transferase, phosphorylation, atp-binding, disease mutation, transmembrane, cell cycle, ec 2.7.10.1, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38007.95
Authors	Yoshikawa, S.,Kukimoto-Niino, M.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Senba, K.,Yamamoto, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-02-06, release date: 2008-02-12, Last modification date: 2023-10-25)
Primary citation	Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Oncogene, 2012 Cited by PubMed: 22349823 DOI: 10.1038/onc.2012.21 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation