3UG2
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 334 | 38038.0 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
2 | A | Gefitinib | non-polymer | 446.9 | 1 | Chemie (IRE) | |||
3 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
4 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 689 | - | expression tag |
Ala 690 | - | expression tag |
Met 691 | - | expression tag |
Gly 692 | - | expression tag |
Ile 693 | - | expression tag |
Arg 694 | - | expression tag |
Ser 719 | Gly 719 | engineered mutation |
Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38038.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 642.1 | |
All* | Total formula weight | 38680.2 |