3VJO

Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.

Summary for 3VJO

• Entry DOI: 10.2210/pdb3vjo/pdb
• Related: 2EB2 2EB3 3UG1 3UG2 3VJN
• Descriptor: Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: receptor, disease mutation, cell cycle, drug resistance, kinase, tyrosine-protein kinase, transferase, atp binding, phosphorylation, transmembrane
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38484.13

Authors

Yoshikawa, S.,Kukimoto-Niino, M.,Shirouzu, M.,Semba, K.,Yamamoto, T.,Yokoyama, S. (deposition date: 2011-10-27, release date: 2012-03-07, Last modification date: 2023-11-08)

• Primary citation: Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S.; Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor.; Oncogene, 32:27-38, 2013; PubMed: 22349823; DOI: 10.1038/onc.2012.21

Experimental method

X-RAY DIFFRACTION (2.64 Å)