3S3O

Crystal structure of the Prototype Foamy Virus (PFV) N224H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572)

3S3O の概要

• エントリーDOI: 10.2210/pdb3s3o/pdb
• 関連するPDBエントリー: 3L2U 3OY9 3OYA 3OYB 3OYK 3OYL 3OYM 3OYN 3S3M 3S3N
• 分子名称: PFV integrase, HEXANE-1,6-DIOL, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (11 entities in total)
• 機能のキーワード: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, recombination-inhibitor-dna complex, recombination/inhibitor/dna
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu), Human foamy virus)
• 細胞内の位置: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101317.84

構造登録者

Hare, S.,Cherepanov, P. (登録日: 2011-05-18, 公開日: 2011-07-13, 最終更新日: 2023-09-13)

• 主引用文献: Hare, S.,Smith, S.J.,Metifiot, M.,Jaxa-Chamiec, A.,Pommier, Y.,Hughes, S.H.,Cherepanov, P.; Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).; Mol.Pharmacol., 80:565-572, 2011; PubMed: 21719464; DOI: 10.1124/mol.111.073189

実験手法

X-RAY DIFFRACTION (2.55 Å)