3S3N
Crystal structure of the Prototype Foamy Virus (PFV) S217H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572)
3S3N の概要
エントリーDOI | 10.2210/pdb3s3n/pdb |
関連するPDBエントリー | 3L2U 3OY9 3OYA 3OYB 3OYK 3OYL 3OYM 3OYN 3S3M 3S3O |
分子名称 | PFV integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ... (10 entities in total) |
機能のキーワード | protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, transferase-inhibitor-dna complex, transferase/inhibitor/dna |
由来する生物種 | Human spumaretrovirus (SFVcpz(hu), Human foamy virus) |
細胞内の位置 | Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 101253.72 |
構造登録者 | |
主引用文献 | Hare, S.,Smith, S.J.,Metifiot, M.,Jaxa-Chamiec, A.,Pommier, Y.,Hughes, S.H.,Cherepanov, P. Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572). Mol.Pharmacol., 80:565-572, 2011 Cited by PubMed: 21719464DOI: 10.1124/mol.111.073189 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.49 Å) |
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