3RM0

Human Thrombin in complex with MI354

Summary for 3RM0
Related1K1O 2ZQ1 3P17 3QTO 3RLW 3RLY 3RM2 3RML 3RMM 3RMN 3RMO
Related PRD IDPRD_001101
DescriptorThrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total)
Functional Keywordsserine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, hirudin, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight36992.94
Authors
Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-04-20, release date: 2012-04-25, Last modification date: 2020-07-29)
Primary citationBiela, A.,Heine, A.,Klebe, G.,Sielaff, F.,Steinmetzer, T.,Terwesten, F.
Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect
J.Med.Chem., 55:6094-6110, 2012
PubMed: 22612268
DOI: 110.1021/jm300337q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.34 Å)
Structure validation
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179210

PDB entries from 2021-06-23