3RBB
HIV-1 NEF protein in complex with engineered HCK SH3 domain
Summary for 3RBB
Entry DOI | 10.2210/pdb3rbb/pdb |
Related | 1AVZ 1EFN 2NEF 3REA 3REB |
Descriptor | Protein Nef, Tyrosine-protein kinase HCK, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | hiv-1 nef, dileucine motif, sh3 domain, receptor internalization, pxxp motif, protein binding, viral protein |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) More |
Cellular location | Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407 Isoform p59-HCK: Membrane; Lipid-anchor. Isoform p60-HCK: Membrane; Lipid-anchor: P08631 |
Total number of polymer chains | 4 |
Total formula weight | 52699.03 |
Authors | Horenkamp, F.A.,Schulte, A.,Weyand, M.,Geyer, M. (deposition date: 2011-03-29, release date: 2011-04-27, Last modification date: 2023-09-13) |
Primary citation | Horenkamp, F.A.,Breuer, S.,Schulte, A.,Lulf, S.,Weyand, M.,Saksela, K.,Geyer, M. Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12:867-877, 2011 Cited by PubMed: 21477083DOI: 10.1111/j.1600-0854.2011.01205.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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