3RBB
HIV-1 NEF protein in complex with engineered HCK SH3 domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 1 |
| Chain | Residue |
| A | ALA180 |
| A | VAL184 |
| C | ARG110 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2 |
| Chain | Residue |
| A | HOH31 |
| A | HOH36 |
| A | TRP106 |
| A | ARG138 |
| A | LEU149 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Region: {"description":"SH3-binding; interaction with Src family tyrosine kinases","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Region: {"description":"Mediates dimerization, Nef-PTE1 interaction","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Region: {"description":"Binding to ATP6V1H","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9620685","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"PxxP; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Dileucine internalization motif; necessary for CD4 internalization","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21477083","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Motif: {"description":"Diacidic; necessary for CD4 internalization","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
