3Q7A
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123
Summary for 3Q7A
Entry DOI | 10.2210/pdb3q7a/pdb |
Related | 3Q73 3Q75 3Q78 3Q79 3Q7F 3SFX 3SFY |
Related PRD ID | PRD_900003 |
Descriptor | Farnesyltransferase alpha subunit, Farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | protein prenyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Cryptococcus neoformans More |
Total number of polymer chains | 2 |
Total formula weight | 100408.63 |
Authors | Hast, M.A.,Beese, L.S. (deposition date: 2011-01-04, release date: 2011-08-03, Last modification date: 2024-02-21) |
Primary citation | Hast, M.A.,Nichols, C.B.,Armstrong, S.M.,Kelly, S.M.,Hellinga, H.W.,Alspaugh, J.A.,Beese, L.S. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286:35149-35162, 2011 Cited by PubMed: 21816822DOI: 10.1074/jbc.M111.250506 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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