3PVU
Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
Summary for 3PVU
Entry DOI | 10.2210/pdb3pvu/pdb |
Related | 1OMW 3CIK 3KRW 3KRX 3PSC 3PVW |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, atp-binding, inhibitor, membrane, transferase-signaling protein-inhibitor complex, transferase/signaling protein/inhibitor |
Biological source | Bos taurus (bovine) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212 |
Total number of polymer chains | 3 |
Total formula weight | 126868.87 |
Authors | Thal, D.M.,Tesmer, J.J. (deposition date: 2010-12-07, release date: 2011-06-01, Last modification date: 2023-09-06) |
Primary citation | Thal, D.M.,Yeow, R.Y.,Schoenau, C.,Huber, J.,Tesmer, J.J. Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol.Pharmacol., 80:294-303, 2011 Cited by PubMed: 21596927DOI: 10.1124/mol.111.071522 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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