3PR0
Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase
3PR0 の概要
エントリーDOI | 10.2210/pdb3pr0/pdb |
関連するPDBエントリー | 2wj1 2wj2 3K7F 3K83 3K84 3ppm |
分子名称 | Fatty Acid Amide Hydrolase 1, 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptane-1,1-diol, CHLORIDE ION, ... (5 entities in total) |
機能のキーワード | protein-inhibitor complex, faah, oxadiazole, alpha-ketoheterocycle, endocannabinoid degradation, membrane protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Rattus norvegicus (rat) |
細胞内の位置 | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 127177.85 |
構造登録者 | Mileni, M.,Han, G.W.,Boger, D.L.,Stevens, R.C. (登録日: 2010-11-29, 公開日: 2011-11-16, 最終更新日: 2023-09-06) |
主引用文献 | Mileni, M.,Garfunkle, J.,Ezzili, C.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133:4092-4100, 2011 Cited by PubMed: 21355555DOI: 10.1021/ja110877y 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
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