3PPM

Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

3PPM の概要

• エントリーDOI: 10.2210/pdb3ppm/pdb
• 関連するPDBエントリー: 2wj1 2wj2 3K7F 3K83 3K84 3PR0
• 分子名称: Fatty-acid amide hydrolase 1, 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptan-1-one, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: protein-inhibitor complex, faah, oxazole, oxadiazole, endocannabinoid degradation, membrane protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127649.30

構造登録者

Mileni, M.,Han, G.W.,Boger, D.L.,Stevens, R.C. (登録日: 2010-11-24, 公開日: 2011-11-09, 最終更新日: 2023-09-06)

• 主引用文献: Mileni, M.,Garfunkle, J.,Ezzili, C.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L.; Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.; J.Am.Chem.Soc., 133:4092-4100, 2011; PubMed: 21355555; DOI: 10.1021/ja110877y

実験手法

X-RAY DIFFRACTION (1.78 Å)