3MDR

Tranylcypromine complex of Cytochrome P450 46A1

3MDR の概要

• エントリーDOI: 10.2210/pdb3mdr/pdb
• 関連するPDBエントリー: 2Q9F 2Q9G 3MDM 3MDT 3MDV
• 分子名称: Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (1R,2S)-2-phenylcyclopropanamine, ... (4 entities in total)
• 機能のキーワード: cyp46a1, p450 46a1, p450, tranylcypromine, monooxygenase, metabolic enzyme, oxidoreductase, heme, cholesterol metabolism, endoplasmic reticulum, iron, lipid metabolism, membrane, metal-binding, microsome, nadp, steroid metabolism, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105749.53

構造登録者

Mast, N.,Charvet, C.,Pikuleva, I.,Stout, C.D. (登録日: 2010-03-30, 公開日: 2010-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Mast, N.,Charvet, C.,Pikuleva, I.A.,Stout, C.D.; Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.; J.Biol.Chem., 285:31783-31795, 2010; PubMed: 20667828; DOI: 10.1074/jbc.M110.143313

実験手法

X-RAY DIFFRACTION (2 Å)