3KZ1
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Summary for 3KZ1
Entry DOI | 10.2210/pdb3kz1/pdb |
Related | 1A2B 1TXD 1X86 1XCG |
Descriptor | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | regulation of rhoa gtpase, rhogef, dh, ph, rho, gtpase activation, guanine-nucleotide releasing factor, membrane, cytoskeleton, gtp-binding, magnesium, nucleotide-binding, prenylation, proto-oncogene, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: O15085 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 |
Total number of polymer chains | 4 |
Total formula weight | 131312.79 |
Authors | Chen, Z.,Sternweis, P.C.,Sprang, S.R. (deposition date: 2009-12-07, release date: 2010-04-28, Last modification date: 2023-09-06) |
Primary citation | Chen, Z.,Medina, F.,Liu, M.Y.,Thomas, C.,Sprang, S.R.,Sternweis, P.C. Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285:21070-21081, 2010 Cited by PubMed: 20430886DOI: 10.1074/jbc.M110.122549 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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