3KZ1
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Rho guanine nucleotide exchange factor 11 | polymer | 383 | 44568.3 | 2 | UniProt (O15085) Pfam (PF00621) Pfam (PF17838) | Homo sapiens (human) | PDZ-RhoGEF |
| 2 | C, D (E, F) | Transforming protein RhoA | polymer | 182 | 20524.5 | 2 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (human) | H12 |
| 3 | E, G (E, F) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, H (E, F) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (GSP) | |||
| 5 | I, J, K, L (A, B, E, F) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B: 710 - 1085 (UniProt: O15085)
E, F: 1 - 181 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Gly 709 | - | expression tag |
| His 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130185.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1127.1 | |
| All* | Total formula weight | 131312.8 |
