3KZ1

Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Rho guanine nucleotide exchange factor 11	polymer	383	44568.3	2	UniProt (O15085) Pfam (PF00621) Pfam (PF17838) In PDB	Homo sapiens (human)	PDZ-RhoGEF
2	E, F	Transforming protein RhoA	polymer	182	20524.5	2	UniProt (P61586) Pfam (PF00071) In PDB	Homo sapiens (human)	H12
3	E, F	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, F	5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE	non-polymer		539.2	2	Chemie (GSP)
5		water	water		18.0	75	Chemie (HOH)

Sequence modifications

A, B: 710 - 1085 (UniProt: O15085)

PDB	External Database	Details
Gly 709	-	expression tag
His 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag
His 1090	-	expression tag
His 1091	-	expression tag

E, F: 1 - 181 (UniProt: P61586)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130185.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1127.1
All*	Total formula weight	131312.8

*Water molecules are not included.