3KZ1

Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA

3KZ1 の概要

• エントリーDOI: 10.2210/pdb3kz1/pdb
• 関連するPDBエントリー: 1A2B 1TXD 1X86 1XCG
• 分子名称: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: regulation of rhoa gtpase, rhogef, dh, ph, rho, gtpase activation, guanine-nucleotide releasing factor, membrane, cytoskeleton, gtp-binding, magnesium, nucleotide-binding, prenylation, proto-oncogene, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: O15085; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131312.79

構造登録者

Chen, Z.,Sternweis, P.C.,Sprang, S.R. (登録日: 2009-12-07, 公開日: 2010-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Chen, Z.,Medina, F.,Liu, M.Y.,Thomas, C.,Sprang, S.R.,Sternweis, P.C.; Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.; J.Biol.Chem., 285:21070-21081, 2010; PubMed: 20430886; DOI: 10.1074/jbc.M110.122549

実験手法

X-RAY DIFFRACTION (2.7 Å)