3KRX

Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)

Summary for 3KRX

Entry DOI	10.2210/pdb3krx/pdb
Related	1BX6 1OMW 3CIK 3KRW
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	rgs homology domain, atp-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transducer, wd repeat, cell membrane, lipoprotein, membrane, methylation, prenylation, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
Total number of polymer chains	3
Total formula weight	125959.85
Authors	Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2009-11-19, release date: 2010-02-16, Last modification date: 2023-09-06)
Primary citation	Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J. Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53:1867-1870, 2010 Cited by PubMed: 20128603 DOI: 10.1021/jm9017515 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation