3KQ6
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Summary for 3KQ6
Entry DOI | 10.2210/pdb3kq6/pdb |
Related | 1RWE |
Descriptor | Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total) |
Functional Keywords | zinc-binding site, long-acting insulin analog, receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 4 |
Total formula weight | 12088.70 |
Authors | Wan, Z.L.,Hu, S.Q.,Whittaker, L.,Phillips, N.B.,Whittake, J.,Ismail-Beigi, F.,Weiss, M.A. (deposition date: 2009-11-17, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Phillips, N.B.,Wan, Z.L.,Whittaker, L.,Hu, S.Q.,Huang, K.,Hua, Q.X.,Whittaker, J.,Ismail-Beigi, F.,Weiss, M.A. Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285:11755-11759, 2010 Cited by PubMed: 20181952DOI: 10.1074/jbc.C110.105825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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