3HC8

Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.

Summary for 3HC8

• Entry DOI: 10.2210/pdb3hc8/pdb
• Related: 1uho 2chm 2h40 2h42 2h44 3bjc 3HDZ
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A, 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one, ZINC ION, ... (5 entities in total)
• Functional Keywords: pde5, pde-5, inhibition, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism allosteric enzyme, cgmp, cgmp-binding, magnesium, metal-binding, nucleotide-binding, zinc
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 37934.56

Authors

Hughes, R.O.,Stallings, W.C.,Cubbage, J.W.,Williams, J.M. (deposition date: 2009-05-05, release date: 2009-07-07, Last modification date: 2024-05-22)

Primary citation

Hughes, R.O.,Walker, J.K.,Cubbage, J.W.,Fobian, Y.M.,Rogier, D.J.,Heasley, S.E.,Blevis-Bal, R.M.,Benson, A.G.,Owen, D.R.,Jacobsen, E.J.,Freskos, J.N.,Molyneaux, J.M.,Brown, D.L.,Stallings, W.C.,Acker, B.A.,Maddux, T.M.,Tollefson, M.B.,Williams, J.M.,Moon, J.B.,Mischke, B.V.,Rumsey, J.M.,Zheng, Y.,Macinnes, A.,Bond, B.R.,Yu, Y.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg.Med.Chem.Lett., 19:4092-4096, 2009

PubMed Abstract: Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency and improved solubility are delineated.

PubMed: 19539468
DOI: 10.1016/j.bmcl.2009.06.004

Experimental method

X-RAY DIFFRACTION (1.79 Å)