3HC8
Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A | polymer | 324 | 37352.0 | 1 | UniProt (O76074) UniProt (P27815) Pfam (PF00233) | Homo sapiens (Human) | cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE,DPDE2,PDE46,cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | B (A) | 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one | non-polymer | 468.5 | 1 | Chemie (PD4) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 536 - 657 (UniProt: O76074)
A: 658 - 681 (UniProt: P27815)
A: 682 - 858 (UniProt: O76074)
A: 658 - 681 (UniProt: P27815)
A: 682 - 858 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Glu 751 | Gln 751 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37352.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 582.6 | |
| All* | Total formula weight | 37934.6 |
