3HC8
Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
Summary for 3HC8
Entry DOI | 10.2210/pdb3hc8/pdb |
Related | 1uho 2chm 2h40 2h42 2h44 3bjc 3HDZ |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A, 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde5, pde-5, inhibition, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism allosteric enzyme, cgmp, cgmp-binding, magnesium, metal-binding, nucleotide-binding, zinc |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 37934.56 |
Authors | Hughes, R.O.,Stallings, W.C.,Cubbage, J.W.,Williams, J.M. (deposition date: 2009-05-05, release date: 2009-07-07, Last modification date: 2024-05-22) |
Primary citation | Hughes, R.O.,Walker, J.K.,Cubbage, J.W.,Fobian, Y.M.,Rogier, D.J.,Heasley, S.E.,Blevis-Bal, R.M.,Benson, A.G.,Owen, D.R.,Jacobsen, E.J.,Freskos, J.N.,Molyneaux, J.M.,Brown, D.L.,Stallings, W.C.,Acker, B.A.,Maddux, T.M.,Tollefson, M.B.,Williams, J.M.,Moon, J.B.,Mischke, B.V.,Rumsey, J.M.,Zheng, Y.,Macinnes, A.,Bond, B.R.,Yu, Y. Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. Bioorg.Med.Chem.Lett., 19:4092-4096, 2009 Cited by PubMed: 19539468DOI: 10.1016/j.bmcl.2009.06.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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