1UHO
Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra)
Summary for 1UHO
Entry DOI | 10.2210/pdb1uho/pdb |
Related | 1UDT 1UDU |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde5 inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38108.62 |
Authors | Sung, B.-J.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Lee, T.G.,Cho, J.M.,Park, S.-Y.,Lee, J.-O.,Jeon, Y.H.,Hwang, K.Y.,Ro, S. (deposition date: 2003-07-09, release date: 2004-07-09, Last modification date: 2023-12-27) |
Primary citation | Sung, B.-J.,Hwang, K.Y.,Jeon, Y.H.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Park, S.-Y.,Lee, J.-O.,Lee, T.G.,Ro, S.,Cho, J.M. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425:98-102, 2003 Cited by PubMed: 12955149DOI: 10.1038/nature01914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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