3HC8

Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.

3HC8 の概要

• エントリーDOI: 10.2210/pdb3hc8/pdb
• 関連するPDBエントリー: 1uho 2chm 2h40 2h42 2h44 3bjc 3HDZ
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A, 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: pde5, pde-5, inhibition, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism allosteric enzyme, cgmp, cgmp-binding, magnesium, metal-binding, nucleotide-binding, zinc
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37934.56

構造登録者

Hughes, R.O.,Stallings, W.C.,Cubbage, J.W.,Williams, J.M. (登録日: 2009-05-05, 公開日: 2009-07-07, 最終更新日: 2024-05-22)

• 主引用文献: Hughes, R.O.,Walker, J.K.,Cubbage, J.W.,Fobian, Y.M.,Rogier, D.J.,Heasley, S.E.,Blevis-Bal, R.M.,Benson, A.G.,Owen, D.R.,Jacobsen, E.J.,Freskos, J.N.,Molyneaux, J.M.,Brown, D.L.,Stallings, W.C.,Acker, B.A.,Maddux, T.M.,Tollefson, M.B.,Williams, J.M.,Moon, J.B.,Mischke, B.V.,Rumsey, J.M.,Zheng, Y.,Macinnes, A.,Bond, B.R.,Yu, Y.; Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.; Bioorg.Med.Chem.Lett., 19:4092-4096, 2009; PubMed: 19539468; DOI: 10.1016/j.bmcl.2009.06.004

実験手法

X-RAY DIFFRACTION (1.79 Å)