3FQC

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)

3FQC の概要

• エントリーDOI: 10.2210/pdb3fqc/pdb
• 関連するPDBエントリー: 3F0B 3F0Q 3F0S 3F0U 3F0V 3F0X 3FQ0 3FQF 3FQO 3FQV 3FQZ
• 分子名称: Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Staphylococcus aureus RF122
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38234.79

構造登録者

Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (登録日: 2009-01-07, 公開日: 2009-03-24, 最終更新日: 2024-04-03)

• 主引用文献: Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C.; Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.; J.Mol.Biol., 387:1298-1308, 2009; PubMed: 19249312; DOI: 10.1016/j.jmb.2009.02.045

実験手法

X-RAY DIFFRACTION (2.35 Å)