Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NDP A 207 |
Chain | Residue |
A | VAL6 |
A | LYS45 |
A | THR46 |
A | LEU62 |
A | THR63 |
A | SER64 |
A | HIS77 |
A | ILE79 |
A | PHE92 |
A | GLY94 |
A | GLN95 |
A | ALA7 |
A | THR96 |
A | LEU97 |
A | GLU100 |
A | THR121 |
A | HOH162 |
A | HOH170 |
A | 55V219 |
A | ILE14 |
A | GLY15 |
A | ASN18 |
A | GLN19 |
A | LEU20 |
A | GLY43 |
A | ARG44 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 55V A 219 |
Chain | Residue |
A | LEU5 |
A | VAL6 |
A | ALA7 |
A | ASP27 |
A | VAL31 |
A | THR46 |
A | SER49 |
A | ILE50 |
A | LEU54 |
A | PHE92 |
A | THR111 |
A | NDP207 |
A | HOH221 |
site_id | AC3 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP B 207 |
Chain | Residue |
B | VAL6 |
B | ALA7 |
B | ILE14 |
B | ASN18 |
B | GLN19 |
B | LEU20 |
B | GLY43 |
B | ARG44 |
B | LYS45 |
B | THR46 |
B | LEU62 |
B | THR63 |
B | SER64 |
B | HIS77 |
B | ILE79 |
B | PHE92 |
B | GLY93 |
B | GLY94 |
B | GLN95 |
B | THR96 |
B | LEU97 |
B | GLU100 |
B | THR121 |
B | HOH167 |
B | HOH190 |
B | HOH199 |
B | 55V219 |
B | HOH223 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 55V B 219 |
Chain | Residue |
B | LEU5 |
B | VAL6 |
B | ALA7 |
B | ASP27 |
B | LEU28 |
B | VAL31 |
B | THR46 |
B | ILE50 |
B | LEU54 |
B | PHE92 |
B | THR111 |
B | HOH160 |
B | NDP207 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
A | VAL13-SER35 | |