3FQ0
Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
Summary for 3FQ0
Entry DOI | 10.2210/pdb3fq0/pdb |
Related | 3F0B 3F0Q 3F0S 3F0U 3F0V 3F0X 3FQC 3FQF 3FQO 3FQV 3FQZ |
Descriptor | Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Staphylococcus aureus RF122 |
Total number of polymer chains | 1 |
Total formula weight | 19073.34 |
Authors | Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (deposition date: 2009-01-06, release date: 2009-03-24, Last modification date: 2024-04-03) |
Primary citation | Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol., 387:1298-1308, 2009 Cited by PubMed: 19249312DOI: 10.1016/j.jmb.2009.02.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
Download full validation report