3F0U
Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine
Summary for 3F0U
Entry DOI | 10.2210/pdb3f0u/pdb |
Related | 3F0B 3F0Q 3F0S 3F0V 3F0X |
Descriptor | Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Staphylococcus aureus RF122 |
Total number of polymer chains | 1 |
Total formula weight | 19135.41 |
Authors | Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (deposition date: 2008-10-26, release date: 2009-03-24, Last modification date: 2024-04-03) |
Primary citation | Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol., 387:1298-1308, 2009 Cited by PubMed: 19249312DOI: 10.1016/j.jmb.2009.02.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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