3F0B

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine

Summary for 3F0B

Entry DOI	10.2210/pdb3f0b/pdb
Related	3F0Q 3F0S 3F0U 3F0V 3F0X
Descriptor	Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Staphylococcus aureus RF122
Total number of polymer chains	1
Total formula weight	19119.41
Authors	Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (deposition date: 2008-10-24, release date: 2009-03-24, Last modification date: 2024-04-03)
Primary citation	Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol., 387:1298-1308, 2009 Cited by PubMed: 19249312 DOI: 10.1016/j.jmb.2009.02.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation