3EBS
Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Phenacetin
Summary for 3EBS
Entry DOI | 10.2210/pdb3ebs/pdb |
Related | 1z10 1z11 2fdu 2fdv 2fdw 2fdy 2p85 2pg5 2pg6 2pg7 |
Descriptor | Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, N-(4-ethoxyphenyl)acetamide, ... (4 entities in total) |
Functional Keywords | cyp2a6, p450 2a6, cyp2a13, p450 2a13, monooxygenase, oxidoreducatase, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome, phenacetin, oxidoreductase, polymorphism |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11509 |
Total number of polymer chains | 4 |
Total formula weight | 221657.89 |
Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2008-08-28, release date: 2008-09-23, Last modification date: 2023-08-30) |
Primary citation | DeVore, N.M.,Smith, B.D.,Urban, M.J.,Scott, E.E. Key residues controlling phenacetin metabolism by human cytochrome P4502A enzymes. Drug Metab.Dispos., 36:2582-2590, 2008 Cited by PubMed: 18779312DOI: 10.1124/dmd.108.023770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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