3E7B

Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin inhibitor Tautomycin

3E7B の概要

• エントリーDOI: 10.2210/pdb3e7b/pdb
• 関連するPDBエントリー: 1FJM 1IT6 1JK7 2BCD 3E7A
• 分子名称: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, MANGANESE (II) ION, (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10R)-10-{(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxopentyl]-1,7-dioxaspiro[5.5]undec-2-yl}-3,7-dihydroxy-2-methoxy-6-methyl-1-(1-methylethyl)-5-oxoundecyl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, ... (8 entities in total)
• 機能のキーワード: protein phosphatase 1, tautomycin, molecular toxin, carbohydrate metabolism, cell cycle, cell division, glycogen metabolism, hydrolase, iron, manganese, metal-binding, phosphoprotein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P62136
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70516.64

構造登録者

Kelker, M.S.,Page, R.,Peti, W. (登録日: 2008-08-18, 公開日: 2008-11-04, 最終更新日: 2023-08-30)

• 主引用文献: Kelker, M.S.,Page, R.,Peti, W.; Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors; J.Mol.Biol., 385:11-21, 2009; PubMed: 18992256; DOI: 10.1016/j.jmb.2008.10.053

実験手法

X-RAY DIFFRACTION (1.7 Å)