3DX3

Golgi alpha-Mannosidase II in complex with Mannostatin analog (1R,2R,3S,4R,5R)-5-aminocyclopentane-1,2,3,4-tetraol

Summary for 3DX3

Related1HTY 1HWW 1HXK 1PS2 1QWN 1R33 1R34 1TQV 2ALW 2F7O 2F7P 2F7Q 2F7R 2FYV 3BUB 3BUP 3CZN 3DX0 3DX1 3DX2 3DX4
DescriptorAlpha-mannosidase 2, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ... (7 entities in total)
Functional Keywordsgh38 glycosidase, glycosidase, golgi apparatus, hydrolase, membrane, metal-binding, signal-anchor, transmembrane
Biological sourceDrosophila melanogaster (Fruit fly)
Cellular locationGolgi apparatus membrane; Single-pass type II membrane protein Q24451
Total number of polymer chains1
Total molecular weight120350.52
Authors
Kuntz, D.A.,Rose, D.R. (deposition date: 2008-07-23, release date: 2009-07-07, Last modification date: 2011-07-13)
Primary citation
Kuntz, D.A.,Zhong, W.,Guo, J.,Rose, D.R.,Boons, G.J.
The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.
Chembiochem, 10:268-277, 2009
PubMed: 19101978 (PDB entries with the same primary citation)
DOI: 10.1002/cbic.200800538
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.42 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.14530.2%0.8%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution