3DX3

Golgi alpha-Mannosidase II in complex with Mannostatin analog (1R,2R,3S,4R,5R)-5-aminocyclopentane-1,2,3,4-tetraol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Alpha-mannosidase 2	polymer	1045	119701.6	1	UniProt (Q24451) Pfam (PF01074) Pfam (PF09261) Pfam (PF21260) Pfam (PF07748) Pfam (PF18230)	Drosophila melanogaster (Fruit fly)	Alpha-mannosidase II, AMAN II, MAN II, Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, Golgi alpha-mannosidase II
2	B (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4) PubChem (1061)
5	E (A)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	1	Chemie (MRD) PubChem (7870) PubChem (5288834) PubChem (5288845)
6	F (A)	(1R,2R,3S,4R,5R)-5-aminocyclopentane-1,2,3,4-tetrol	non-polymer		149.1	1	Chemie (YTB) PubChem (10261237) PubChem (10351853) PubChem (11987837) PubChem (13880378) PubChem (17758491) PubChem (42628065) PubChem (55284179) PubChem (55281173) PubChem (55284180) PubChem (55285611) PubChem (133669885) PubChem (135038555)
7	G (A)	water	water		18.0	1399	Chemie (HOH)

Sequence modifications

A: 13 - 1045 (UniProt: Q24451)

PDB	External Database	Details
Arg 1	-	expression tag
Ser 2	-	expression tag
Ser 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Gly 10	-	expression tag
Glu 11	-	expression tag
Phe 12	-	expression tag
Lys 907	Glu 970	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	119701.6
Non-Polymers*	Number of molecules	5
	Total formula weight	648.9
All*	Total formula weight	120350.5

*Water molecules are not included.