3AE0

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with geranylgeranyl thiopyrophosphate

3AE0 の概要

• エントリーDOI: 10.2210/pdb3ae0/pdb
• 関連するPDBエントリー: 2ZCO 2ZCP 2ZCQ 2ZCR 2ZCS 2ZY1 3ADZ
• 分子名称: Dehydrosqualene synthase, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: crtm, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation, geranylgeranyl thiopyrophosphate, ggspp
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71434.66

構造登録者

Liu, C.I.,Jeng, W.Y.,Wang, A.H.J.,Oldfield, E. (登録日: 2010-01-31, 公開日: 2010-11-24, 最終更新日: 2023-11-01)

• 主引用文献: Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E.; Mechanism of action and inhibition of dehydrosqualene synthase.; Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010; PubMed: 21098670; DOI: 10.1073/pnas.1010907107

実験手法

X-RAY DIFFRACTION (2.37 Å)