2Z7X

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Summary for 2Z7X

• Entry DOI: 10.2210/pdb2z7x/pdb
• Related: 2Z80 2Z81 2Z82
• Descriptor: Toll-like receptor 2,Variable lymphocyte receptor B, (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, Toll-like receptor 1,Variable lymphocyte receptor B, ... (11 entities in total)
• Functional Keywords: tlr2, tlr1, pam3csk4, lipopeptide, innate immunity, glycoprotein, immune response, inflammatory response, leucine-rich repeat, membrane, receptor, transmembrane, cytoplasmic vesicle, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 126181.40

Authors

Lee, J.O.,Jin, M.S.,Kim, S.E.,Heo, J.Y. (deposition date: 2007-08-29, release date: 2007-10-02, Last modification date: 2024-02-07)

• Primary citation: Jin, M.S.,Kim, S.E.,Heo, J.Y.,Lee, M.E.,Kim, H.M.,Paik, S.G.,Lee, H.,Lee, J.O.; Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide; Cell(Cambridge,Mass.), 130:1071-1082, 2007; PubMed: 17889651; DOI: 10.1016/j.cell.2007.09.008

Experimental method

X-RAY DIFFRACTION (2.1 Å)