2Z7X
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Toll-like receptor 2,Variable lymphocyte receptor B | polymer | 549 | 62236.1 | 1 | UniProt (O60603) UniProt (Q4G1L2) Pfam (PF00560) Pfam (PF13855) In PDB | Homo sapiens (human) | Toll/interleukin-1 receptor-like protein 4 |
2 | B | Toll-like receptor 1,Variable lymphocyte receptor B | polymer | 520 | 59367.2 | 1 | UniProt (Q15399) UniProt (Q4G1L2) Pfam (PF13855) In PDB | Homo sapiens (human) | Toll/interleukin-1 receptor-like protein,TIL |
3 | C | Pam3CSK4 | polymer | 6 | 725.0 | 1 | synthetic construct | ||
4 | D | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G52260VY) | |||
5 | E | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
6 | F | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
7 | G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G90333CG) | |||
8 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
9 | C | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
10 | C | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate | non-polymer | 568.9 | 1 | Chemie (Z41) | |||
11 | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
A: 27 - 508 (UniProt: O60603)
A: 509 - 575 (UniProt: Q4G1L2)
B: 25 - 476 (UniProt: Q15399)
B: 478 - 544 (UniProt: Q4G1L2)
A: 509 - 575 (UniProt: Q4G1L2)
B: 25 - 476 (UniProt: Q15399)
PDB | External Database | Details |
---|---|---|
Ser 477 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 122328.3 | |
Branched | Number of molecules | 4 |
Total formula weight | 2143.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1710.2 | |
All* | Total formula weight | 126181.4 |