2YLY

Sulfonamides as selective Estrogen Receptor beta Agonists.

Summary for 2YLY

• Entry DOI: 10.2210/pdb2yly/pdb
• Related: 1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 2FSZ 2JJ3
• Descriptor: ESTROGEN RECEPTOR BETA, N-cyclopropyl-4-oxidanyl-N-[(2R)-2-oxidanyl-2-phenyl-propyl]benzenesulfonamide, SULFATE ION (3 entities in total)
• Functional Keywords: receptor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: Q92731
• Total number of polymer chains: 2
• Total formula weight: 55189.43

Authors

Roberts, L.R.,Armour, D.,Barker, C.,Bazin, R.,Bess, K.,Brown, A.,Favor, D.,Ellis, D.,MacKenny, M.,Pullen, N.,Stennett, A.,Strand, L.,Styles, M.,Phillips, C. (deposition date: 2011-06-06, release date: 2012-06-13, Last modification date: 2024-05-08)

Primary citation

Roberts, L.R.,Armor, D.,Barker, C.,Bent, A.,Bess, K.,Brown, A.,Favor, D.A.,Ellis, D.,Irving, S.L.,Mackenny, M.,Phillips, C.,Pullen, N.,Stennett, A.,Strand, L.,Styles, M.
Sulfonamides as Selective Oestrogen Receptor Beta Agonists.
Bioorg.Med.Chem.Lett., 21:5680-, 2011

PubMed Abstract: A series of p-hydroxybenzenesulphonamides ERβ receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERα receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERβ agonists.

PubMed: 21885279
DOI: 10.1016/J.BMCL.2011.08.041

Experimental method

X-RAY DIFFRACTION (3.2 Å)