2JJ3

Estrogen receptor beta ligand binding domain in complex with a Benzopyran agonist

Summary for 2JJ3

• Entry DOI: 10.2210/pdb2jj3/pdb
• Related: 1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 2FSZ
• Descriptor: ESTROGEN RECEPTOR BETA, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3 entities in total)
• Functional Keywords: phosphorylation, steroid-binding, nuclear receptor, transcription regulation, alternative splicing, ligand binding domain, zinc, nucleus, receptor, zinc-finger, dna-binding, transcription, metal-binding, lipid-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: Q92731
• Total number of polymer chains: 2
• Total formula weight: 59110.07

Authors

Norman, B.H.,Richardson, T.I.,Dodge, J.A.,Pfeifer, L.A.,Durst, G.L.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Dinn, S.R.,Liu, S.,Reilly, J.E.,Ryter, K.T. (deposition date: 2007-07-03, release date: 2007-08-07, Last modification date: 2011-07-13)

• Primary citation: Norman, B.H.,Richardson, T.I.,Dodge, J.A.,Pfeifer, L.A.,Durst, G.L.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Dinn, S.R.,Liu, S.,Reilly, J.E.,Ryter, K.T.; Benzopyrans as Selective Estrogen Receptor Beta Agonists (Serbas). Part 4: Functionalization of the Benzopyran A-Ring.; Bioorg.Med.Chem.Lett., 17:5082-, 2007; PubMed: 17662603; DOI: 10.1016/J.BMCL.2007.07.009

Experimental method

X-RAY DIFFRACTION (2.28 Å)