1YY4
Crystal structure of estrogen receptor beta complexed with 1-chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
Summary for 1YY4
Entry DOI | 10.2210/pdb1yy4/pdb |
Related | 1YYE |
Descriptor | Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL, ... (4 entities in total) |
Functional Keywords | estrogen receptor, estrogen receptor beta, er-beta, er, estrogen, nuclear receptor, transcription factor, agonist, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9UEV6 |
Total number of polymer chains | 4 |
Total formula weight | 63359.14 |
Authors | Mewshaw, R.E.,Edsall Jr., R.J.,Yang, C.,Manas, E.S.,Xu, Z.B.,Henderson, R.A.,Keith Jr., J.C.,Harris, H.A. (deposition date: 2005-02-23, release date: 2006-02-28, Last modification date: 2024-02-14) |
Primary citation | Mewshaw, R.E.,Edsall Jr., R.J.,Yang, C.,Manas, E.S.,Xu, Z.B.,Henderson, R.A.,Keith Jr., J.C.,Harris, H.A. ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity J.Med.Chem., 48:3953-3979, 2005 Cited by PubMed: 15943471DOI: 10.1021/jm058173s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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