2XUM
FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)
Summary for 2XUM
Entry DOI | 10.2210/pdb2xum/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ASP-SUBSTRATE PEPTIDE 2, ZINC ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase-peptide complex, non-heme, dioxygenase, oxygenase, hypoxia, metal-binding, helix-loop-helix-beta, facial triad signaling, beta-hydroxylation, transcription activator/inhibitor, oxidoreductase/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 43072.50 |
Authors | Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-19, release date: 2010-12-22, Last modification date: 2023-12-20) |
Primary citation | Yang, M.,Ge, W.,Chowdhury, R.,Claridge, T.D.,Kramer, H.B.,Schmierer, B.,McDonough, M.A.,Gong, L.,Kessler, B.M.,Ratcliffe, P.J.,Coleman, M.L.,Schofield, C.J. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J. Biol. Chem., 286:7648-7660, 2011 Cited by PubMed: 21177872DOI: 10.1074/jbc.M110.193540 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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